Digital pathology slide with AI cell segmentation
Pathology Annotation

Pathology Annotation by Board-Certified Pathologists

Whole-slide image annotation for surgical pathology, cytology, IHC, and hematopathology. Gigapixel-scale precision from subspecialty-matched pathologists.

Subspecialties We Cover

Surgical Pathology

Tumor identification, margin assessment, grading, staging on H&E stained tissue

Cytology

Cell-level classification, Pap smear analysis, fine needle aspiration specimens

Immunohistochemistry (IHC)

Biomarker expression scoring (HER2, Ki-67, PD-L1), staining intensity grading

Frozen Sections

Intraoperative consultation annotations, rapid tumor margin assessment

Hematopathology

Blood smear classification, bone marrow analysis, lymphoma subtyping

Dermatopathology

Skin biopsy annotation, melanoma detection, inflammatory pattern classification

Annotation Types

Our pathologists deliver the annotation types your digital pathology AI models require, from coarse tissue-level labels to single-cell precision:

  • Region of interest (ROI) marking: delineation of tumor beds, necrosis zones, and diagnostic areas across whole-slide images
  • Cell-level segmentation: individual cell boundary annotation for cell counting, morphology analysis, and spatial profiling
  • Tissue classification: pixel-level labeling of tumor vs. normal vs. necrosis vs. stroma for tissue composition analysis
  • Mitotic figure counting: identification and marking of mitotic figures for proliferation assessment and tumor grading
  • Gleason grading: pattern-by-pattern annotation of prostate cancer tissue with Gleason score assignment
  • Tumor budding quantification: identification and counting of tumor buds at the invasive front for prognostic scoring

Why LabelCore for Pathology

Digital pathology AI depends on annotations from pathologists who understand tissue morphology at a diagnostic level. LabelCore.AI does not use medical students or general annotators for pathology work. Every whole-slide image is annotated by a board-certified pathologist with subspecialty expertise matching the tissue type and clinical question.

Our platform handles gigapixel-scale whole-slide images natively. Pathologists annotate directly on SVS, NDPI, and MRXS files at any magnification, from 1x overview to 40x oil immersion equivalent. No downsampling, no tile artifacts, no loss of diagnostic detail.

For multi-stain workflows, we support registered serial section annotation where pathologists cross-reference H&E morphology with IHC biomarker expression. This enables training data for models that integrate morphological and molecular features, which is critical for companion diagnostic AI development.

Quality Tiers for Pathology

TierAccuracyMethodBest For
Gold Standard99%Multi-pathologist consensusFDA submissions, companion diagnostics
Hybrid93%AI pre-segmentation + pathologist validationModel training, algorithm development
Ready Datasets85%Pre-labeled, instant downloadResearch, proof of concept

Frequently Asked Questions

What pathology subspecialties do your annotators cover?+
Our annotator network includes board-certified pathologists across all major subspecialties: surgical pathology, cytopathology, hematopathology, dermatopathology, neuropathology, and GI pathology. Each case is assigned to a pathologist with relevant subspecialty training and clinical experience.
Do you support whole-slide images?+
Yes. LabelCore.AI provides native support for whole-slide image formats including SVS (Aperio), NDPI (Hamamatsu), MRXS (3DHISTECH), and TIFF. Our platform handles gigapixel-scale images with tiled rendering so pathologists can annotate at any magnification level without format conversion.
How do you handle multi-stain annotations?+
We support registered multi-stain workflows for serial sections. Pathologists can annotate H&E alongside IHC stains (e.g., HER2, Ki-67, PD-L1) with cross-referenced regions of interest. Stain-specific scoring protocols are calibrated per project requirements.
What accuracy can I expect for pathology annotation?+
Our Gold Standard tier delivers 99% accuracy through multi-pathologist consensus with complete audit trails. Each annotation undergoes independent review by a second board-certified pathologist. Hybrid Intelligence provides 93% accuracy using AI-assisted pre-segmentation validated by pathologists.
Can annotations support digital pathology AI development?+
Absolutely. Our annotations are optimized for training digital pathology AI models including tumor detection, cancer grading (Gleason, Nottingham), biomarker quantification (Ki-67 index, PD-L1 TPS/CPS), and tissue classification. We export in formats compatible with QuPath, ASAP, and all major ML frameworks.

Start Your Pathology Annotation Project

Share your tissue type, staining protocol, and volume requirements. We match you with subspecialty pathologists within 48 hours.